구강편평세포암종에서 막형 제1형 금속함유 단백분해 효소의 발현
Membrane Type I-Matrix Metalloproteinase, MT1-MMP
소속 상세정보
명훈/Myeng H
홍성두/이재일/임창윤/김명기/홍삼표/Hong SD/Lee JI/Lim CY/Kim MK/Hong SP
KMID : 0829220020260010041
Abstract
Local invasion and lymph node metastasis(LNM) which cause poor prognosis of oral squamous cell carcinoma(OSCC) require the degradation of extracellular matrix by multiple proteolytic enzymes including membrane type I MMP(MT1-MMP). The purpose of this study was to evaluate the expression of MT1-MMP was examined in 46 OSCCs via immunohistochemistry and non-radioisotope in-냐셔 hybridization. The relationship between MT1-MMP was examined in 46 OSCCs via immunohistochemistry and non-radioisotope in-situ hybridization. The relationship between MT1-MMP expression and LNM, and histological invasiveness was statistically analyzed, and following results were obtsined. Whereas 12 of the 18 OSCCs(66.7%) with LNM showed moderate to strong MT1-MMP expression, 9 of the 28 OSCCs(32.1%) without LNM showed strong expression. MT1-MMP expression was significantly increased in regard to LNM(P=0.012). As invasion grade became strong(from grade A to grade D), MT1-MMP was expressed significantly strong(P=0.033). Theses results suggest that MT1-MMP is involved in the invasiveness and LNM of OSCC, and MT1-MMP combined with other markers could be used as a marker predicting the metastatic potential of OSCC.
Membrane type I matrix metalloproteinase(MT1-MMP); oral squamous cell carcinoma; lymph node metastasis; invasion
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원문 및 링크아웃 정보
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